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HelpTest Code ACETA Acetaminophen
CPT
80143
Specimen Type
Blood
Preferred Collection Container
GRN-PST
Collection Volume
3 mL
Minimum Collection Volume
1 mL
Collection Instructions
Routine venipuncture, When evaluating possible toxicity, 4-hour post ingestion sample should be drawn.
Rejection Criteria
Specimen not stored properly, grossly lipemic, hemolyzed and icteric specimens, Inadequate labeling, improper collection.
Specimen Storage and Stability
Separate serum and refrigerate.
Turn Around Time
24 hours; Stats – 2 hours
Lab Department
Chemistry
Alias
Acetaminophen, Serum; Datril; Liquiprin; Paracetamol; Tempra; Tylenol; Anacin-3; Panadol; Panex;
EPIC Code
LAB43
Acceptable Collection Container
GRN-PST, SST, R-NoGel, G-NoGel
Testing Volume
0.2 mL (200 ul)
Patient Preparation
Therapeutic monitoring should be drawn 30-60 minutes post oral dose. (Peak), (Trough): Prior to next dose.
Additional Information
Acetaminophen is rapidly absorbed from the gastrointestinal tract, with peak levels occurring 1-3 hours after ingestion. Serum levels drawn less than 4 hours after ingestion may not represent peak levels.The normal half-life of the drug is approximately 3 hours. A half-life of greater than 4 hours indicates impaired metabolism and potential for hepatic injury. Toxicity due to acetaminophen should be monitored by determining both serum concentration and rate of clearance (half-life). An elevated serum acetaminophen with a half life of greater than 4 hours indicates a high likelihood of hepatic injury. The hepatic toxicity of acetaminophen is related to the formation of one or more highly reactive metabolites in the liver. Orally administered N-acetylcysteine (Mucomyst) has been shown to provide protection against acetaminophen toxicity. The patient’s condition should be monitored clinically for hepatotoxicity. Liver function tests may be indicated
Day(s) and Time(s) Performed
Monday through Sunday, 24 hours
LOINC
3298-7