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Test Code TPMRBC Thiopurine Methyltransferase, RBC Phenotype  

Important Note

Phenotype test to assess risk for severe myelosuppression with standard dosing of thiopurine drugs. Testing should be performed prior to initiation of thiopurine therapy.  For therapy optimization or toxicity evaluation, order Thiopurine Metabolites
 

Additional Codes

92066

Specimen Type

Whole Blood

Preferred Collection Container

PINK

Collection Instructions

Routine venipuncture

Collection Volume

5.0 mL

Minimum Collection Volume

3.0 mL

Testing Volume

3.0 mL

Rejection Criteria

Gel separator tubes. Specimens collected in sodium fluoride/potassium oxalate (gray). Hemolyzed, frozen, or room temperature specimens.

Specimen Storage and Stability

Ambient: 3 hours; Refrigerated: 6 days; Frozen: Unacceptable

Day(s) and Time(s) Performed

Sunday through Saturday

Test Alias

92066, TPMT, TPMT Erythrocytes, TPMT-RBC, TPMT Enzyme
 

CPT Coding

84433

EPIC Code

LAB2448A

Methodology

Enzymatic/Quantitative Liquid Chromatography-Tandem Mass Spectrometry
 

Acceptable Collection Container

LAV (venipuncture), PINK (K2EDTA) OR 6ML LAV (K2EDTA)
 

Transport

Refrigerated

Turn Around Time

4-6 days

LOINC

53819-9